Koichiro Kinugawa Selected Research

Nitrogen

1/2018	Novel Risk Score Efficiently Prevents Tolvaptan-Induced Hypernatremic Events in Patients With Heart Failure.
6/2015	Ratio of urine and blood urea nitrogen concentration predicts the response of tolvaptan in congestive heart failure.
1/2013	Urine osmolality estimated using urine urea nitrogen, sodium and creatinine can effectively predict response to tolvaptan in decompensated heart failure patients.

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Koichiro Kinugawa Research Topics

Disease

128	Heart Failure 07/2022 - 06/2005
19	Atrial Fibrillation 03/2022 - 01/2013
11	Systolic Heart Failure 07/2022 - 10/2020
10	Aortic Valve Stenosis (Aortic Stenosis) 02/2022 - 01/2016
10	Hyponatremia 09/2019 - 01/2012
9	Neoplasms (Cancer) 04/2022 - 01/2012
9	Pulmonary Arterial Hypertension 01/2020 - 09/2006
7	Chronic Renal Insufficiency 08/2022 - 01/2013
7	Ventricular Tachycardia 06/2022 - 09/2012
7	Cardiogenic Shock 05/2022 - 09/2019
7	Hypertrophy 05/2016 - 12/2002
6	Hypotension (Low Blood Pressure) 11/2021 - 01/2014
6	Left Ventricular Dysfunction 10/2021 - 01/2013
6	Disease Progression 03/2021 - 01/2013
6	Tachycardia (Tachyarrhythmias) 10/2020 - 01/2013
6	Death (Near-Death Experience) 09/2016 - 12/2009
5	Ventricular Fibrillation 06/2022 - 05/2003
5	Hypertension (High Blood Pressure) 01/2022 - 01/2015
5	Pulmonary Hypertension 01/2022 - 01/2011
5	Anemia 12/2021 - 01/2014
4	Mitral Valve Insufficiency (Mitral Regurgitation) 05/2022 - 07/2020
4	Hyperkalemia 05/2022 - 01/2021
4	Hemorrhage 03/2022 - 01/2012
4	Type 2 Diabetes Mellitus (MODY) 01/2022 - 09/2019
4	Hypernatremia 01/2018 - 01/2014
4	Stroke (Strokes) 12/2017 - 01/2012
3	Thrombosis (Thrombus) 03/2022 - 03/2020
3	Hypokalemia 11/2021 - 01/2014
3	Glomerulonephritis 11/2021 - 01/2021
3	Infections 01/2021 - 01/2012
3	Cardiomyopathies (Cardiomyopathy) 07/2020 - 01/2015
3	Body Weight (Weight, Body) 09/2019 - 01/2013
3	Fibrosis (Cirrhosis) 08/2019 - 05/2003
3	Myocardial Ischemia (Ischemic Heart Diseases) 10/2017 - 05/2003
3	Low Cardiac Output 02/2017 - 01/2014
3	Cardiomegaly (Heart Hypertrophy) 01/2016 - 04/2005
2	Myocarditis (Carditis) 09/2022 - 06/2022
2	Constipation 05/2022 - 01/2022
2	Cardiac Tamponade 04/2022 - 01/2021
2	Fever (Fevers) 01/2022 - 05/2021
2	Rare Diseases (Rare Disease) 01/2022 - 11/2021
2	Sinus Tachycardia 01/2022 - 04/2021
2	Amyloidosis 01/2022 - 04/2021
2	Hypoxia (Hypoxemia) 12/2021 - 12/2021
2	Acute Coronary Syndrome 10/2021 - 09/2019
2	Tricuspid Valve Insufficiency (Insufficiency, Tricuspid Valve) 09/2021 - 07/2021
2	IGA Glomerulonephritis (IGA Nephropathy) 05/2021 - 04/2021

Drug/Important Bio-Agent (IBA)

30	Tolvaptan FDA Link 01/2022 - 01/2012
15	DiureticsIBA 09/2019 - 01/2012
13	IvabradineIBA 07/2022 - 10/2020
12	Brain Natriuretic Peptide (Natrecor)FDA Link 01/2022 - 09/2009
11	SodiumIBA 01/2022 - 01/2012
9	Vasopressins (Vasopressin)IBA 09/2019 - 01/2013
7	PotassiumIBA 05/2022 - 01/2014
6	Arginine Vasopressin (Argipressin)IBA 08/2022 - 01/2014
6	Pharmaceutical PreparationsIBA 05/2022 - 12/2017
6	landiololIBA 10/2020 - 01/2013
5	Sodium-Glucose Transport ProteinsIBA 01/2022 - 01/2021
5	Bosentan (Tracleer)FDA Link 01/2015 - 01/2011
4	Aquaporin 2IBA 08/2022 - 01/2014
4	sodium zirconium cyclosilicateIBA 05/2022 - 01/2021
4	sacubitril and valsartan sodium hydrate drug combinationIBA 01/2022 - 01/2021
4	Biomarkers (Surrogate Marker)IBA 10/2021 - 01/2013
4	Carvedilol (Coreg)FDA LinkGeneric 03/2021 - 09/2006
4	Vasopressin Receptors (Arginine Vasopressin Receptor)IBA 09/2019 - 01/2015
4	CreatinineIBA 09/2019 - 01/2013
4	Everolimus FDA Link 05/2016 - 01/2012
3	Hemoglobins (Hemoglobin)IBA 04/2022 - 04/2021
3	Mineralocorticoid Receptor AntagonistsIBA 01/2022 - 01/2021
3	Prealbumin (Transthyretin)IBA 01/2022 - 07/2020
3	Digoxin (Digitek)FDA LinkGeneric 10/2020 - 01/2013
3	Urea (Carbamide)FDA LinkGeneric 01/2018 - 01/2013
3	NitrogenIBA 01/2018 - 01/2013
3	Sildenafil Citrate (Viagra)FDA Link 09/2015 - 01/2011
3	Imatinib Mesylate (Gleevec)FDA Link 01/2015 - 07/2010
2	Indicators and Reagents (Reagents)IBA 05/2022 - 03/2016
2	AnticoagulantsIBA 03/2022 - 01/2012
2	Serum AlbuminIBA 01/2022 - 06/2015
2	ProdrugsIBA 01/2022 - 01/2012
2	Prolyl Hydroxylases (Prolyl Hydroxylase)IBA 12/2021 - 12/2021
2	Prolyl-Hydroxylase InhibitorsIBA 12/2021 - 12/2021
2	EnzymesIBA 12/2021 - 01/2015
2	esaxerenoneIBA 11/2021 - 05/2021
2	Fibronectins (Fibronectin)IBA 11/2021 - 08/2019
2	Enalapril FDA LinkGeneric 10/2021 - 01/2021
2	Sodium-Glucose Transporter 2 InhibitorsIBA 07/2021 - 07/2021
2	tafamidisIBA 04/2021 - 07/2020

Therapy/Procedure

72	Therapeutics 07/2022 - 01/2011
41	Heart-Assist Devices 05/2022 - 01/2011
15	Heart Transplantation (Grafting, Heart) 01/2022 - 01/2011
11	Catheter Ablation 06/2022 - 07/2016
10	Transcatheter Aortic Valve Replacement 02/2022 - 01/2016
6	Drug Therapy (Chemotherapy) 01/2022 - 01/2012
5	Extracorporeal Membrane Oxygenation 09/2022 - 01/2015
5	Cardiac Resynchronization Therapy 05/2022 - 01/2015
5	Catheters 04/2022 - 04/2020
4	Mechanical Ventilators (Ventilator) 09/2022 - 01/2016
3	Transplantation 03/2016 - 07/2011
3	Defibrillators (Defibrillator) 06/2015 - 09/2012
2	Positive-Pressure Respiration (Positive End-Expiratory Pressure) 09/2021 - 01/2017